COVID-19’s Self-Replication Machinery Exposed to Drug Designers

If you want to disrupt COVID-19’s intricate self-replication machinery—and bring the virus to a screeching halt—you can’t simply throw a spanner in the works. Instead, you need to create a some intricate machinery of your own, machinery that will mesh just so with COVID-19’s most vulnerable parts. Perhaps no part of COVID-19 is more vulnerable than its main protease. COVID-19 needs its main protease, which is called Mpro or 3CLpro, to form a viral replication complex. This protease could be inhibited by an antiviral drug, provided the protease and the drug had complementary 3D shapes. Fortunately, the task of designing a drug that fits just go a little easier, thanks to a structural study completed by scientists based at the University of Lübeck. Using high-intensity X-ray light from the BESSY II facility of the Helmholtz-Zentrum Berlin, these scientists have elucidated the main protease’s 3D structure. Details of the structure appeared March 20 in the journal Science, in an article entitled, “Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.” In this article, X-ray structures are reported for the unliganded SARS-CoV-2 ...

Peacock Release Date Announced! All subscription details

The new NBC transmission service, Peacock, will be officially born on April 15, 2020 for Xfinity X1 and Flex customers. Today, the platform released this news during the presentation of Comcast NBCUniversal investors at the iconic Studio 8H 30 Rock. The platform not only confirmed the early release date of April 2020 (and a national debut of July 15, 2020), but also gave more details about the subscription options for the streaming service, which includes free levels with advertising. As previously joked, Peacock is programmed to offer consumers everything they love to see, in an accessible place. “This is a very exciting time for our company, as we trace the future of entertainment.” Steve Burke, President of NBCUniversal, said in a statement. “We have one of the most enviable media brand collections and the strongest ad sales history in the business. Taking advantage of these key strengths, we are taking a unique approach to streaming that adds value to customers, advertisers and shareholders.” Through Peacock (and its subscription levels), viewers will have access to more than 600 movies and 400 series, as well as various live and on-demand content in ...

Encore Wire Welcomes Successful Completion of Trade Remedy Case Against Imports of Aluminum Wire and Cable From China

Encore Wire Corporation (NASDAQ Global Select: WIRE) today commented on the unanimous final affirmative vote of the U.S. International Trade Commission (ITC) in the ongoing antidumping (AD) and countervailing duty (CVD) investigations of Aluminum Wire and Cable from China. “We are pleased that the ITC has unanimously confirmed our claims that imports of aluminum wire from China were being illegally subsidized and dumped into the U.S. market, and were undermining our investments in aluminum wire production, which is an important complement to our copper building wire business. This final vote marks the successful completion of a case that the U.S. Government initiated in October 2018,” said Daniel Jones, Chairman, President, and Chief Executive Officer of Encore Wire Corporation. As a result of the ITC’s final affirmative decision, U.S. importers of aluminum wire and cable from China will be required to pay antidumping duties at rates ranging from 47.83 percent to 52.79 percent, plus countervailing duties at rates ranging from 33.44 percent to 165.63 percent, depending upon the Chinese exporter/supplier. The Commerce Department is scheduled to publish its final AD and CVD orders...

ALMOST a decade after it set the bar for compact crossovers through its distinctive personality and

ALMOST a decade after it set the bar for compact crossovers through its distinctive personality and emphasis on fun, the next generation Nissan JUKE is set to arrive to reinvent the segment once again. The Japanese car maker has worked hard to deliver new levels of performance and technology, within a striking yet roomier coupe crossover body, all bundled up in a package that is larger than ever before. The next generation JUKE features Nissan’s Intelligent Mobility system, and ProPILOT, which adds in-car WiFi, over the air software updates and smart phone connectivity, including Apple CarPlay and Android Auto, and TomTom mapping. Safety technology gets a big lift too, with intelligent emergency braking with pedestrian and cyclist recognition, traffic sign recognition, intelligent lane intervention, rear cross traffic alert and blind spot intervention. The new JUKE also features a more athletic stance, 19-inch alloy wheels and a coupe style ‘floating roof’ design, while full LED lighting is now standard. The latest version of the JUKE also retains its iconic circular headlamps. These now form part of a new Y-shaped signature which complements Nissan’s V-Motion grille, while an ...